Oncolytics Biotech is conducting clinical trials in multiple indications with the objective of developing REOLYSIN® as a human cancer therapeutic. Oncolytics’ clinical development program emphasizes three pillars: chemotherapy combinations to trigger selective tumor lysis; immuno-therapy combinations to produce adaptive immune responses; and immune modulator (IMiD) combinations to facilitate innate immune responses. Oncolytics is currently planning its first registration study in breast cancer, as well as studies in combination with checkpoint inhibitors and IMID/targeted therapies in solid and hematological malignancies.
|Trial Number||Phase||Trial Name||Indication||Status|
||Phase Ib||Intravenous Administration of REOLYSIN in Combination with Pembrolizumab (KEYTRUDA®) and Chemotherapy in Patients with Advanced or Metastatic Pancreatic Adenocarcinoma||Pancreatic Cancer||Complete|
||Phase II||Intravenous Administration of REOLYSIN in Combination with Paclitaxel and Carboplatin for Patients with Metastatic Pancreatic Cancer||Pancreatic Cancer||Complete|
||Phase II||Intravenous Administration of REOLYSIN in Combination with Gemcitabine (Gemzar®) for Patients with Advanced or Metastatic Pancreatic Cancer||Pancreatic Cancer||Complete|
REOLYSIN® is currently available in a clinical trial setting only. It has not been approved in any jurisdiction and is not available for purchase. The Company, its directors, officers, employees and affiliates have no influence over the inclusion of a patient in a clinical trial. Should a patient’s physician determine that he or she may be a suitable clinical trial candidate, they must contact a participating center. Contact information, as well as inclusion and exclusion criteria, for both US and international participating centers can be found at www.clinicaltrials.gov for studies with a US component.